Tools
GLP-1 titration calculator
By An NayalLast reviewed 9 sources
GLP-1 medications are started low and stepped up over weeks to ease stomach side effects. This tool lays out that timeline: load a published label schedule, or enter a start dose, a step size, and a ceiling, and see the week-by-week plan and how long it takes to reach the top dose.
Load a published schedule
Or build a custom escalation
Semaglutide - Wegovy
From the FDA labelSteps
5
Top dose
2.4 mg
Weeks to top dose
16
Weeks charted
20
| Step | Weeks | Dose |
|---|---|---|
| 1 | Weeks 1-4 | 0.25 mg |
| 2 | Weeks 5-8 | 0.5 mg |
| 3 | Weeks 9-12 | 1 mg |
| 4 | Weeks 13-16 | 1.7 mg |
| 5 | Week 17 onward | 2.4 mg |
The last row is the maintenance dose, held from that week onward - the four-week window shown is just where escalation ends.
Not charted: 7.2 mg (after at least 4 weeks at 2.4 mg). Optional 'Wegovy HD' step, FDA-approved March 19, 2026 - only for patients who have tolerated 2.4 mg and whose prescriber confirms more weight reduction is needed; not a step everyone on 2.4 mg takes.
What the source says: The label says that if a patient does not tolerate a dose during escalation, the prescriber may delay the increase by 4 weeks.
Schedule math and a reference layout only. This lays out a timeline from the numbers entered or from a published schedule - it does not tell you what dose to take or how fast to escalate. GLP-1 medications are prescription drugs; dosing and escalation are decisions for you and a licensed prescriber, based on the actual product you hold.
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Worked example
The calculator opens on the Wegovy injection preset. It reads each dose from the FDA label schedule and gives every step the label's four-week window:
- Step 1, weeks 1-4: 0.25 mg
- Step 2, weeks 5-8: 0.5 mg
- Step 3, weeks 9-12: 1 mg
- Step 4, weeks 13-16: 1.7 mg
- Step 5, week 17 onward: 2.4 mg
The summary reads 5 steps, a top dose of 2.4 mg, 16 weeks to the top dose, and 20 weeks charted. The 16 comes from four steps of four weeks before 2.4 mg begins. The last row says "onward" because 2.4 mg is the maintenance dose, held from week 17; the 20 weeks charted is only where the table stops drawing it. The label also lists an optional 7.2 mg "Wegovy HD" step for some patients after at least four weeks at 2.4 mg. It is not part of the standard escalation, so the table leaves it out and notes it below.
The custom fields start filled with a 0.25 mg start, a 0.25 mg step, 4 weeks per step and a 2.4 mg max. Type into any of them and the calculator switches to a custom build from those numbers. With the seed values it adds 0.25 mg every four weeks: 0.25, 0.5, 0.75, and so on up to 2.25 mg in weeks 33-36. The next step would be 2.5 mg, which is over the max, so it is clamped to 2.4 mg for weeks 37-40. That gives 10 steps, 36 weeks to the top dose and 40 total weeks. The gap between 16 and 36 weeks is why the presets copy the label's uneven steps rather than using a fixed increment.
How the math works
A titration schedule is arithmetic on a calendar. Each step holds one dose for a number of weeks, and the next step starts the week after.
week start = 1 + weeks of all earlier steps
week end = week start + weeks per step - 1
In the custom builder the dose rises by the same increment each step and stops at the max. The final step is clamped down so it lands exactly on the max instead of overshooting it.
dose at step n = min(start + n x increment, max), for n = 0, 1, 2 ...
The summary figures come from the last row. "Weeks to top dose" is the week the last step starts, minus one. "Total weeks" (or "weeks charted" on a preset) is the week the last step ends.
A few edge cases follow from the code. An increment of 0 gives a single flat step. The start dose must be above zero and no higher than the max, and weeks per step must be a whole number, or the calculator asks you to fix the inputs instead of drawing a table. Doses are rounded to six decimal places to clear floating-point noise and shown with up to three, and a build stops at 500 steps so a tiny increment cannot run forever.
The label presets skip the increment formula. Their doses are read from the label schedules on our reference pages and laid out step by step, which is how semaglutide's 1 to 1.7 to 2.4 mg jumps render without distortion. This is schedule math and a reference layout, not a recommendation to take any dose.
Sources
- [1]WEGOVY (semaglutide) injection - DailyMed label, Novo NordiskSemaglutideAdult weekly escalation: 0.25 mg (wk 1-4), 0.5 mg (wk 5-8), 1 mg (wk 9-12), 1.7 mg (wk 13-16), 2.4 mg maintenance (wk 17+); delay escalation 4 weeks if a dose is not tolerated
- [2]FDA Approves Fourth Product Under National Priority Voucher Program, Higher Dose Semaglutide (Wegovy HD, 7.2 mg) - FDA press announcement, March 19, 2026SemaglutideFDA approval of a 7.2 mg Wegovy maintenance dose for patients who have tolerated 2.4 mg and need additional weight reduction, based on the Phase 3 STEP UP trial program
- [3]OZEMPIC (semaglutide) injection - DailyMed label, Novo Nordisk (Revised 5/2026)SemaglutideWeekly escalation: 0.25 mg start (4 wk), 0.5 mg, then 1 mg after >=4 wk, then 2 mg maximum after >=4 wk if additional glycemic control is needed
- [4]RYBELSUS (semaglutide) oral tablets - DailyMed label, Novo Nordisk (Revised 1/2026)SemaglutideOral daily escalation: 3 mg (days 1-30, not for glycemic control), 7 mg (days 31-60), 14 mg maximum (day 61+ if more control needed)
- [5]FDA Approves Novo Nordisk's Wegovy Pill, the First and Only Oral GLP-1 for Weight Loss in Adults - PR Newswire, December 22, 2025SemaglutideFDA approval and titration schedule (1.5 mg, 4 mg, 9 mg, 25 mg maintenance) for the oral Wegovy tablet, distinct from Rybelsus
- [6]ZEPBOUND (tirzepatide) injection - DailyMed label, Eli Lilly (Revised 4/2026)TirzepatideStart 2.5 mg once weekly for 4 weeks, increase in 2.5 mg increments after at least 4 weeks up to a 15 mg maximum; maintenance 5/10/15 mg (weight) or 10/15 mg (OSA)
- [7]MOUNJARO (tirzepatide) injection - DailyMed label, Eli Lilly (Revised 4/2026)TirzepatideStart 2.5 mg once weekly, increase to 5 mg after 4 weeks, then 2.5 mg increments after >=4 weeks if needed; maximum 15 mg adults, 10 mg pediatric 10+
- [8]Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial - Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526. PMID 37366315.RetatrutideRandomized to retatrutide 1, 4 (initial 2 or 4 mg), 8 (initial 2 or 4 mg), or 12 mg (initial 2 mg) or placebo once weekly for 48 weeks; 12 mg produced -24.2% mean weight change vs -2.1% placebo
- [9]A Study of Retatrutide (LY3437943) in Participants With Obesity - ClinicalTrials.gov NCT04881760RetatrutideTrial record confirming the dose arms and starting-dose stratification (2 mg or 4 mg initial, escalating to 4, 8, or 12 mg target) for the Phase 2 obesity study
Questions people ask
How many weeks does it take to reach 2.4 mg on the Wegovy schedule?
On the Wegovy label schedule the calculator loads, 2.4 mg starts in week 17. It follows four steps of four weeks each (0.25, 0.5, 1 and 1.7 mg), so escalation takes 16 weeks. That is the label's minimum; a prescriber can hold a step longer.
How long does it take to reach 15 mg of tirzepatide?
The Zepbound preset has six steps of four weeks: 2.5, 5, 7.5, 10, 12.5 and 15 mg. The 15 mg step starts in week 21, after 20 weeks of escalation. The label says each step lasts at least four weeks, so 20 weeks is the shortest path.
Why doesn't the custom builder match the semaglutide label?
The custom builder adds the same amount at every step. The semaglutide label does not: it goes 0.25, 0.5, 1, 1.7, then 2.4 mg. A fixed 0.25 mg step to 2.4 mg takes 10 steps and 36 weeks instead. The presets copy the label's steps as written, so use those when you want the label schedule.
Why is there no week-by-week table for retatrutide?
Retatrutide is investigational and has no FDA label. Its published Phase 2 trial gives the dose sequence (2, 4, 8 and 12 mg in the highest arm) but not the week each step happened, so the calculator shows the dose ladder only and does not invent a timeline.
Can I share or save a schedule?
Yes. The page address updates as you pick a preset or type custom numbers, for example ?preset=tirzepatide or ?mode=custom&start=2.5&step=2.5&wk=4&max=15. Bookmark or send that link and it opens with the same schedule. Nothing is stored on our side.
Pepteca is for education and information only. It does not provide medical advice, diagnosis, or treatment, and its calculators perform unit math only. Always verify with a licensed provider before starting, changing, or stopping any protocol. Many peptides are not approved for human use and may be regulated differently where you live.